依维莫司引起的口腔炎如何处理
我母亲现在正在服用“飞尼妥”，5mg ,qd.服药时间7天，发现非常严重的口腔炎，牙龈肿痛的难以忍受，从服药开始每天均用“康复新”口服液漱口。按时刷牙，不知该如何解决？请各位赐教。非常感谢！ Dosage modifications (SEGA)Avoid strong CYP3A4 inducers if other therapy is available
If coadministration with strong CYP3A4 inducer required, double initial dose; base subsequent doses on serum concentration; readjust dose if strong CYP3A4 inducer is discontinued
Avoid strong CYP3A4 inhibitors
Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL
Severe hepatic impairment (Child-Pugh class C): Reduce dose by 50%; base subsequent doses on serum concentrations
Mild-to-moderate hepatic impairment: Adjustment to the recommended starting dose may not be needed; however, subsequent dosing should be based on therapeutic drug monitoring
Reduce dose or withhold for severe or intolerable adverse reactions; reduce dose by ~50%; if dose reduction required while receiving lowest available strength, administer every other day
http://reference.medscape.com/drug/afinitor-zortress-everolimus-999101
减量服用。 复方氯己定漱口水、口服维生素B族、维生素C
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