发给老马备查:
7 d ]0 d1 |( K滴水察海(69304838) 15:23:23! ] v' m1 z$ w$ m* }4 e( s X% t
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱. \: |4 B3 _& f3 U, k$ G
吉非替尼和S-1连用的依据, S, p) \) ~7 E0 [8 B, k4 E
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.+ Y" O# Y* z9 V, l9 D9 I" ]4 R6 y6 i
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* n& }' H- J- a( B; p1 u4 ^% H, ?这样是不是推理出,耐药后,可以用S-1和培美了?
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如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |